Freenos SR Drug Interactions

When administered concomitantly with alcohol, loratadine has no potentiating effect as measured by psychomotor performance studies.
When sympathomimetic agents are given to patients receiving MAO inhibitors, hypertensive reactions, including hypertensive crises, may occur.
The antihypertensive effects of methyldopa, mecamylamine, reserpine and veratrum alkaloids may be reduced by sympathomimetic agents.
Beta-adrenergic blocking agents may also interact with sympathomimetic agents.
Antacids increase the rate of pseudoephedrine absorption; kaolin decreases it.
Increased ectopic pacemaker activity can occur when pseudoephedrine is used concomitantly with digitalis.
The antibacterial agent, furazolidone, is known to cause a dose-related inhibition of MAO. Although there are no reports of a hypertensive crisis caused by the concurrent administration of pseudoephedrine and furazolidone, they should not be taken together.
Care should be taken in the administration of FREENOS SR concomitantly with other sympathomimetic amines because the combined effects on the cardiovascular system may be harmful to the patient.
Increases in plasma concentrations of loratadine have been reported after concomitant use with ketoconazole, erythromycin or cimetidine, but without clinically significant changes (including electrocardiographic).
Other drugs known to inhibit hepatic metabolism should be coadministered with caution.
Loratadine should be discontinued approximately 48 hours prior to skin testing procedures since antihistamines may prevent or diminish otherwise positive reactions to dermal reactivity indicators.
The in vitro addition of pseudoephedrine to sera containing the cardiac isoenzyme MB of serum creatine phosphokinase progressively inhibits the activity of the enzyme. The inhibition becomes complete over six hours.